Drug Interactions With Sprintec

Many Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Sprintec too quickly, increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Modafinil (Provigil)
Modafinil may make Sprintec less effective, increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Protease Inhibitors
Using Sprintec together with a protease inhibitor may increase your risk of pregnancy and may make the protease inhibitor less effective. Talk with your healthcare provider before using Sprintec with a protease inhibitor.
Selegiline (Eldepryl, Emsam, Zelapar)
The hormones in Sprintec may increase the level of selegiline in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your selegiline dosage or may recommend an alternate form of contraception.
St. John's Wort
St. John's wort (a commonly used herbal supplement) may decrease the effectiveness of Sprintec, increasing the chance of pregnancy. In general, you should not take St. John's wort while using Sprintec.
Theophylline (Uniphyl, Theocron, TheoCap, Theo-24, Elixophyllin)
Sprintec may increase the level of theophylline in your blood, increasing the chance of theophylline side effects. Talk with your healthcare provider before taking these medications together. Your theophylline dose may need to be reduced, or you may need to switch to a different method of contraception.

Final Thoughts on Sprintec Drug Interactions

It is possible that not every drug interaction with Sprintec was discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the Sprintec drug interactions that may apply to you.
Last reviewed by: Kristi Monson, PharmD
Pregnancy and Pain