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Vitamin B12 Drug Interactions
If you take folic acid, H2 blockers, or proton pump inhibitors in combination with vitamin B12, drug interactions may occur. These interactions could decrease the absorption of the vitamin. In order to reduce your risk of negative interactions, make sure to tell your healthcare provider about all other medications and supplements you are taking before using vitamin B12 supplementation.
Vitamin B12 can potentially interact with a few different medicines. Some of the medicines that may lead to drug interactions with vitamin B12 include:
- Chloramphenicol
- Folic acid
- H2 blockers, such as:
- Cimetidine (Tagamet®)
- Famotidine (Pepcid®)
- Nizatidine (Axid®)
- Ranitidine (Zantac®)
- Metformin (Fortamet®, Glucophage®, Glucophage XR®, Glumetza™, Riomet®)
- Proton pump inhibitors (PPIs), including:
- Dexlansoprazole (Dexilant™)
- Esomeprazole (Nexium®)
- Lansoprazole (Prevacid®, Prevacid® 24HR)
- Omeprazole (Prilosec®, Prilosec OTC®)
- Omeprazole and sodium bicarbonate (Zegerid®, Zegerid OTC™)
- Pantoprazole (Protonix®)
- Rabeprazole (AcipHex®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD