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Vitamin B6 Drug Interactions

If phenytoin, amiodarone, or phenobarbital is taken in combination with vitamin B6, drug interactions could occur. These interactions may increase your sensitivity to the sun or reduce the effectiveness of the medications. In order to minimize your risk of developing drug interactions with this vitamin, tell your healthcare provider about all other medicines you are taking before using it.

An Introduction to Vitamin B6 Drug Interactions

Vitamin B6 (pyridoxine) can potentially interact with a few different medicines. Some of the medicines that may lead to vitamin B6 drug interactions include:

Vitamin B6 Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when vitamin B6 is combined with any of the drugs listed above.
Amiodarone
Some studies suggest that vitamin B6 may increase the risk of sun sensitivity due to amiodarone, although other studies have not shown this effect. Be aware that you may be more sensitive to the sun. It is a good idea to use sunscreen if you will be out in the sun.
Phenobarbital
Early research suggests that vitamin B6 may decrease the level of phenobarbital in the blood, perhaps making it less effective. If you take phenobarbital, do not start (or stop) taking high doses of vitamin B6 without your healthcare provider's supervision.
Phenytoin
Early research suggests that vitamin B6 may decrease the level of phenytoin in the blood, perhaps making it less effective. If you take phenytoin, do not start (or stop) taking high doses of vitamin B6 without your healthcare provider's supervision.

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‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
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