Vitamin B6 Safety

It is important to discuss the safety of vitamin B6 with your healthcare provider, even though it is a "natural" supplement. Evidence suggests that the vitamin may do more harm than good when used after coronary stenting, so let your healthcare provider know if you've had a coronary stent. Also, tell him or her about all medications you are taking to prevent drug interactions with vitamin B6.

Is Vitamin B6 Safe to Take?

Vitamin B6 (pyridoxine) is a relatively safe substance, especially when taken at reasonable dosages. However, some people may be more likely to experience problems due to the vitamin. You should talk with your healthcare provider prior to taking vitamin B6 if you:
  • Have had a coronary stent
  • Have any allergies, including allergies to foods, dyes, or preservatives
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Warnings and Precautions

Warnings and precautions to be aware of concerning the safety of vitamin B6 include the following:
  • Preliminary evidence suggests that vitamin B6 (in combination with folic acid and vitamin B12) may actually do more harm than good when used after coronary stenting. This combination of supplements may actually increase the risk of re-narrowing ("restenosis") of the coronary artery.
  • Vitamin B6 toxicity is possible, especially with high doses. Although the symptoms of toxicity (such as numbness or tingling sensations) are usually reversible once the vitamin is stopped, some severe cases may cause long-lasting problems.
  • Vitamin B6 can interact with some medications (see Vitamin B6 Drug Interactions for more information).
  • Normal intakes of vitamin B6 are safe for pregnant or breastfeeding women (see Vitamin B6 and Pregnancy and Vitamin B6 and Breastfeeding).

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Last reviewed by: Kristi Monson, PharmD
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