Vitamin B6 Side Effects

While most people do not experience any problems while taking vitamin B6, it is possible for side effects to occur. Mild side effects that have been reported with the supplement include mild drowsiness, vomiting, and abdominal pain. Some side effects of vitamin B6 are more serious and should be reported to your healthcare provider immediately, including coordination problems and numbness or unusual sensations in the hands or feet.

An Overview of Vitamin B6 Side Effects

Most people can take vitamin B6 (pyridoxine) at reasonable doses without experiencing significant side effects. However, vitamin B6 side effects can occur. These side effects are probably most common at high doses and may sometimes be a sign of vitamin B6 toxicity.

Possible Side Effects of Vitamin B6

Reported vitamin B6 side effects that are bothersome (but usually not dangerous) include:
  • Nausea
  • Vomiting
  • Abdominal pain (stomach pain)
  • Headaches
  • Mild drowsiness
  • Sensitivity to the sun
  • Breast enlargement or breast pain.

Serious Side Effects

Some possible side effects of vitamin B6 are more serious and should always be reported to your healthcare provider. These side effects (which may be signs of a dangerous reaction to vitamin B6 or signs that your vitamin B6 dosage is too high) include:
  • Numbness or unusual sensations (such as tingling), often in the hands or feet
  • Coordination problems, due to lack of sensation in the limbs
  • Signs of an allergic reaction, such as:


    • Hives or a rash
    • Itching
    • Swelling of the lips, mouth, or throat
    • Wheezing or other difficulty breathing.

More Headlines in Vitamin B6 Side Effects

‣ Final Thoughts
Last reviewed by: Kristi Monson, PharmD
The Zen of Cancer Caregiving - Recharge Your Batteries!