Hydroxyprogesterone Caproate Drug Information

If you have given birth prematurely in the past, your healthcare provider may recommend hydroxyprogesterone caproate (MakenaTM). This product is a long-acting, synthetic version of the hormone progesterone. In clinical studies, 37.1 percent of women receiving this drug delivered before 37 weeks, compared to 54.9 percent of women receiving injections that contained no active ingredients.
Hydroxyprogesterone caproate is given as a weekly injection and is tolerated well by most women. If side effects do occur, they are generally mild and easily treated. Some of the commonly reported side effects include swelling and pain at the injection site.
Before starting treatment with hydroxyprogesterone caproate, make sure your healthcare provider has up-to-date information on any other medications you are taking, including nonprescription drugs, vitamins, and supplements. Also, you may not be able to safely use this medication if you have certain medical conditions, such as liver or heart problems.
(Click Hydroxyprogesterone Caproate for more information on this drug. Topics discussed in this article include dosing guidelines, other safety issues to be aware of before beginning treatment, and more.)
Last reviewed by: Arthur Schoenstadt, MD