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Yaz Drug Interactions

Atorvastatin (Lipitor)
Atorvastatin may increase the level of Yaz in your blood, which may increase your risk of Yaz side effects. Check with your healthcare provider before taking these medications together.
Barbiturates
Barbiturates may cause your body to metabolize the hormones in Yaz too quickly, which could increase your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a barbiturate.
Certain Seizure Medications
Some seizure medications may cause your body to metabolize the hormones in Yaz too quickly, possibly increasing your risk of pregnancy. Ask your healthcare provider if you should use a different method of contraception while taking a seizure medication.
Cyclosporine (Gengraf, Neoral, Sandimmune)
Yaz may increase the level of cyclosporine in your blood, possibly increasing the chance of side effects of cyclosporine. Talk with your healthcare provider before taking these medications together. Your cyclosporine dose may need to be reduced, or you may need to switch to a different method of contraception.
Heparin
Combining Yaz with heparin can increase the risk of high potassium levels in your blood (hyperkalemia). Your healthcare provider should regularly check your potassium levels if you are taking both of these medications.
Modafinil (Provigil)
Modafinil can make Yaz less effective, possibly increasing your risk of pregnancy. Talk with your healthcare provider, as you may need to use a backup method of contraception.
Nonsteroidal Anti-Inflammatory Drugs (NSAIDs)
Taking Yaz with NSAIDs can increase the risk of high potassium levels in your blood (hyperkalemia). Occasional use of NSAIDs in healthy women who take Yaz should not typically cause a problem. However, check with your healthcare provider if you take NSAIDs regularly or if you take a large NSAID dosage.
Last reviewed by: Kristi Monson, PharmD
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