A healthcare provider may prescribe sibutramine to help people lose weight and to help prevent people from regaining the weight they lost. It is available as a capsule that is taken once a day. The medication works by increasing the levels of certain chemicals in the brain, causing a sense of fullness. Potential side effects of sibutramine include insomnia, headaches, and constipation.

What Is Sibutramine?

In October 2010, sibutramine hydrochloride was withdrawn from the market in the United States. Studies have shown that it increases the risk of heart attacks and strokes. This medication will no longer be available in the United States. People should stop taking it and should ask their healthcare providers about more appropriate weight loss options. 
Sibutramine hydrochloride monohydrate (Meridia®) is a prescription weight loss medication. Not only is the drug approved to help people lose weight; it is also approved to help people from regaining the weight they have lost.
(Click What Is Sibutramine Used For? for more information, including possible off-label uses.)

Sibutramine Side Effects

As with any medicine, side effects are possible with sibutramine. However, not everyone who takes the drug will experience side effects. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider. Serious side effects are less common.
Common side effects include but are not limited to:
(Click Side Effects of Sibutramine to learn more, including potentially serious side effects you should report immediately to your healthcare provider.)
Last reviewed by: Kristi Monson, PharmD
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